Tuberculosis
Tuberculosis, more commonly known as “TB”, is thought by many to be a disease of the past. However, TB is very much a reality in many parts of the world including here in the Northwest Territories.
What is Tuberculosis?
Tuberculosis is a contagious disease caused by a type of bacteria called Mycobacterium tuberculosis. The germ enters the lung, and grows slowly. It may not become active for many years. TB most commonly stays in the lung, but may also be carried through the blood to other areas such as the kidneys, bones or the brain. TB is easily treated with antibiotics if identified early. Individuals who have been infected with the TB germ, but who have not yet developed active TB, can also be prescribed medication to prevent them from becoming sick in the future.
How is it Spread?
TB is spread when someone who has TB coughs, sneezes, laughs, sings or even talks loudly and contaminates the air with tiny droplets that contain live germs. If such droplets are then breathed in by someone else, that person becomes "infected". Tuberculosis is most commonly spread when people are together in small, enclosed spaces that have poor ventilation. The TB germs must be breathed in from the air; you cannot get TB by touching things like door knobs or sharing food and utensils.
Being "infected" does not mean that you have active TB. People may remain well for many years while the TB germs remain in an inactive state. Active TB disease usually develops over a period of several months or even years, often when the immune system is weakened (for example, the elderly or those with HIV). When TB is not active, it cannot be spread to others. The only way to know if you have become infected is to be tested.
What are the symptoms of active TB?
The symptoms of TB vary from person to person depending on the severity of the disease. In the early stages there may be no symptoms at all. As the disease advances, the most common symptoms include:
- a cough which does not go away;
- night sweats;
- fever;
- weight loss;
- chest pain; and
- fatigue.
Anyone who has persistent symptoms should have a check up by a nurse or physician. At that time, a skin test and/or a chest x-ray will be done and sputum (spit) samples will need to be sent for testing.
How can I find out if I have TB germs?
There are two kinds of TB tests used to identify if you have latent TB. The most common one is a TB skin test. Sometimes a blood test is also required to confirm that someone has latent TB.
What happens if someone tests positive for TB?
A positive TB skin test usually indicates the presence of latent TB, which is a dormant form of TB that is not contagious. However, 5-10% of people may develop TB disease at a later time in their life, with children being at highest risk. You will get a chest x-ray and possibly be asked to collect sputum (spit) to check that you do not have active TB disease. If the presence of latent TB is confirmed, you will be advised to take medicine to prevent active TB disease from developing at a later time.
Active TB disease of the lungs is usually contagious, so people with TB disease are isolated in a special hospital room until sufficient treatment has been received. Another sputum test will be done to confirm that the person is no longer contagious.
As well, public health nurses conduct a contact investigation for all cases of active TB disease. The purpose of a contact investigation is to identify and treat anyone else with TB disease and to identify and offer preventative treatment for latent TB (latent refers to the condition that is not contagious). The number of contacts varies depending on how contagious the sick person was; how long they were sick before beginning treatment; and how many people they were in contact with.
What can I do to ensure I don’t get TB?
Advise your doctor or nurse if you are aware that you have been in contact with someone with active TB disease. Get a TB test and return for a second TB test if your health care provider says you need one. Take medicine to prevent TB if and as recommended. Exercise regularly, avoid smoking, and eat a healthy diet to avoid chronic diseases that can increase the likelihood of TB disease developing from latent TB.
What is the difference between active TB disease and latent TB infection?
A person with active TB disease usually feels unwell and has symptoms. Active TB disease in the lungs is contagious and is spread by coughing, singing, sneezing, and speaking. People with active TB disease may have an abnormal chest x-ray and positive lab tests for TB.
People who have latent TB infection do not feel sick and have no symptoms. The TB germs in their body are in a “latent” state (dormant, inactive, or sleeping). People with latent TB infection will usually have a positive skin test (TST) and usually have a normal chest x-ray and negative lab tests. Latent TB infection is not contagious and does not spread to other people. About 5-10% of people with latent TB infection go on to develop TB disease.
Links
- Tuberculosis(link is external) (Government of Canada)
- Tuberculosis: Get Tested, Get Treated and Get Cured!(link is external) (Health Canada)
TB Skin Test (Mantoux Test)
- The TB skin test, also known as the Mantoux test, tells if your body has been exposed to the TB germ.
- The nurse will inject a small amount of fluid just under the skin of the left forearm.
- You will see a little bubble or blister appear right away at the injection site. This is normal and it will soon disappear.
- After 2-3 days, you will be asked to see the nurse to have the area checked and the reaction measured.
- If there is no reaction after 2-3 days, you most probably have not been exposed to the TB germ.
- If there is a reaction, some redness and a small bump will appear on the arm.
- A measurement of 10 millimetres or more is "positive", and means you may have the TB germ in your body. At that point, the nurse will request additional information and tests, including chest x-ray and the collection of sputum samples. When results are abnormal, the nurse will then consult with a medical health officer who may then recommend a further course of action.
Bacille Calmette-Guérin (BCG) Vaccine
What is BCG vaccine?
BCG is a vaccine containing live, weakened tuberculosis germs that activate a person’s immune system. Countries have used BCG for almost 100 years. Globally, about 100 million children receive BCG yearly. BCG protects infants and young children from severe presentations of tuberculosis such as TB Meningitis and Disseminated TB. There is uncertainty about whether BCG protects people from tuberculosis infections after infancy.
What is Tuberculosis (TB)?
TB is an infection that can cause disease in any part of the body but most often the lungs. If a person breathes in a TB germ, it may cause a long-term TB infection that does not cause any symptoms. In some people with TB infection, the TB germ multiplies and causes TB disease. TB disease in the lungs can cause symptoms like coughing and fever. When a person with TB disease coughs, the germ goes into the air, and others around that person can breathe in the germ and become infected too.
Is BCG vaccine safe?
BCG vaccine is safe for most infants. BCG is a live bacteria and infants with severe immune deficiencies cannot receive BCG.
BCG vaccine causes a small raised bump that can swell and leak fluid 2-4 weeks after the vaccine. This usually heals within 2-5 months and usually leaves a small scar.
BCG often causes a lymph node in the armpit or above the collarbone to swell—this is a normal immune system response. There is a low risk of a lymph node becoming infected. If you find a lump after BCG, talk to your healthcare provider.
A BCG vaccine in the first year of life may result in a future false positive tuberculin skin test (TST) up to the age of 10. TSTs help diagnose TB infections.
There is a very rare chance of a severe allergic reaction called anaphylaxis. Anaphylaxis can occur with any vaccine or medication. Anaphylaxis results in hives, rash, swelling of the lips or tongue, and difficulty breathing. Anaphylaxis typically occurs within 15 minutes of receiving a vaccine so we recommend that you stay in the clinic for 15 minutes after getting the vaccine. Your healthcare provider is trained to treat anaphylaxis.
What is the risk of not getting BCG vaccine?
BCG protects from severe forms TB in infants and children. The rates of TB infection are much higher in some parts of the NWT compared to Canada as a whole.
Reasons an infant may not be eligible to receive BCG vaccine
Tell your healthcare provider if your baby has any of the following:
- Immune system concerns such as:
- Taking medications that affect the immune system
- HIV positive
- Born to HIV positive or unknown HIV status mother
- The birth mother was on immune suppressing medications during pregnancy or while breastfeeding
- Having a family member with Severe Combined Immunodeficiency (SCID)
- Positive TST or active TB disease
- Allergy to the vaccine or its components
- Burns or other serious skin problems
- Is older than 12 months of age
- Positive SCID test
BCG and Severe Combined Immunodeficiency (SCID)
Severe Combined Immunodeficiency (SCID) is a group of rare genetic conditions that affects the body’s ability to fight infections. Children born with SCID who don’t receive treatment develop frequent severe infections.
All infants in the Northwest Territories are tested for SCID at birth.
Babies that have SCID cannot receive any live vaccine because their immune system does not work normally. If BCG is given to a child with SCID, there is the potential for a severe infection.
BCG in the NWT was previously given at birth but is now given after you and your healthcare provider know the results of your baby’s SCID test.
BCG vaccine aftercare
After your infant receives BCG vaccine:
- Wash your baby’s arm normally
- Place a cool damp compress over any swelling
- If the sore is draining, cover it with a dry, dressing that is not waterproof (e.g. gauze)
- DO NOT:
- Squeeze, pop, or scratch the site
- Put cream or ointment on it
- Put a band aid on the sore
- Rub or massage the site
If you are concerned about a reaction with the vaccine, talk to your healthcare provider.